The Grey Sloan doctors treat a patient who encountered illegal fireworks; Bailey has her sights set on hiring new doctors, but she's having trouble finding viable options; Owen and Teddy attempt to take the next step in their engagement.
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Meredith seeks advice from Amelia; Richard is re-energized as he takes teaching to a new level at the hospital; Winston treats a patient suffering from kidney failure.
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Seattle's favorite redhead returns and graces the Grey Sloan halls with her experience and expertise as she attempts to help Richard teach the newest crop of residents.
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Richard recruits Meredith and Bailey to help him launch a new program. Meanwhile, Addison's patient has complications from a procedure, and Jo helps a woman who goes into premature labor.
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The Grey Sloan doctors spring into action after an explosion rocks Seattle, with the incoming trauma hitting close to home. Owen experiences PTSD after he hears the explosion, while his sister Megan enlists help from Winston and Hayes in confidence. In Minnesota, Meredith and Amelia meet up with a familiar face who assists in their study.
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It's Thanksgiving, and Meredith has travel problems due to the weather; Amelia and Link reconnect.
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Dr. Hamilton takes his frustrations out on Meredith, so Nick gives her a chance to blow off steam by scrubbing in on a surgery; Link and Jo take their kids to a fairy-tale theater performance that goes wrong.
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The doctors celebrate the holidays; Hamilton and Meredith prepare for a milestone on their project; Link wants to spend the holiday with Amelia and Scout as a family; Schmitt is faced with a difficult decision during surgery.
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The Grey Sloan Memorial doctors grapple with the aftermath of the car crash that involved some of their own; Meredith works to save Dr. Hamilton's life; Levi is impacted from his latest loss.
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Schmitt faces the Morbidity and Mortality conference; Hayes says his goodbyes without revealing his real reason for leaving; Hunt's and Farouk's conditions each begin to improve after their surgeries; Jo acknowledges her feelings for Link.